South Sister ranks No. 35 among the 57 ultra-prominent peaks in the contiguous United States, rising 10,363 feet in the Cascade Range of central Oregon with 5,590 feet of clean prominence. It is the highest of the Three Sisters volcanoes and Oregon's third-highest summit within the Three Sisters Wilderness. Most hikers use the South Sister Climber Trail from Devil's Lake for 13 miles round-trip with 4,950 feet of gain on Class 2 terrain. Central Cascades Wilderness permits are required June 15 through October 15 via Recreation.gov.
Geologically, South Sister is the youngest of the Three Sisters volcanoes; its most recent eruption occurred about 2,000 years ago, and the USGS has documented earthquake swarms and ground uplift southwest of the summit in recent decades. The mountain supports several glaciers, including Prouty Glacier, widely cited as Oregon's largest glacier. At the summit crater sits Teardrop Pool, commonly cited as the highest lake in Oregon. Unlike North Sister and many snowy-season routes on Middle Sister, South Sister's standard summer route is nontechnical and accessible to fit hikers in good conditions, which accounts for its status as a high-demand day-use permit in the Central Cascades Wilderness system.